Characterization of RNA polymerase II trigger loop mutations using molecular dynamics simulations and machine learning

Catalysis and fidelity of multisubunit RNA polymerases rely on a highly conserved active site domain called the trigger loop (TL), which achieves roles in transcription through conformational changes and interaction with NTP substrates. The mutations of TL residues cause distinct effects on catalysi...

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Detalles Bibliográficos
Autores principales: Dutagaci, Bercem, Duan, Bingbing, Qiu, Chenxi, Kaplan, Craig D., Feig, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069792/
https://www.ncbi.nlm.nih.gov/pubmed/36947548
http://dx.doi.org/10.1371/journal.pcbi.1010999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069792/
https://www.ncbi.nlm.nih.gov/pubmed/36947548
http://dx.doi.org/10.1371/journal.pcbi.1010999

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