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Characterization of RNA polymerase II trigger loop mutations using molecular dynamics simulations and machine learning
Catalysis and fidelity of multisubunit RNA polymerases rely on a highly conserved active site domain called the trigger loop (TL), which achieves roles in transcription through conformational changes and interaction with NTP substrates. The mutations of TL residues cause distinct effects on catalysi...
Autores principales: | Dutagaci, Bercem, Duan, Bingbing, Qiu, Chenxi, Kaplan, Craig D., Feig, Michael |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069792/ https://www.ncbi.nlm.nih.gov/pubmed/36947548 http://dx.doi.org/10.1371/journal.pcbi.1010999 |
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