Mu opioid receptor-mediated release of endolysosome iron increases levels of mitochondrial iron, reactive oxygen species, and cell death

OBJECTIVES: Opioids including morphine and DAMGO activate mu-opioid receptors (MOR), increase intracellular reactive oxygen species (ROS) levels, and induce cell death. Ferrous iron (Fe(2+)) through Fenton-like chemistry increases ROS levels and endolysosomes are “master regulators of iron metabolis...

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Detalles Bibliográficos
Autores principales: Halcrow, Peter W., Kumar, Nirmal, Hao, Emily, Khan, Nabab, Meucci, Olimpia, Geiger, Jonathan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070011/
https://www.ncbi.nlm.nih.gov/pubmed/37027339
http://dx.doi.org/10.1515/nipt-2022-0013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070011/
https://www.ncbi.nlm.nih.gov/pubmed/37027339
http://dx.doi.org/10.1515/nipt-2022-0013

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