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Mu opioid receptor-mediated release of endolysosome iron increases levels of mitochondrial iron, reactive oxygen species, and cell death

OBJECTIVES: Opioids including morphine and DAMGO activate mu-opioid receptors (MOR), increase intracellular reactive oxygen species (ROS) levels, and induce cell death. Ferrous iron (Fe(2+)) through Fenton-like chemistry increases ROS levels and endolysosomes are “master regulators of iron metabolis...

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Detalles Bibliográficos
Autores principales:	Halcrow, Peter W., Kumar, Nirmal, Hao, Emily, Khan, Nabab, Meucci, Olimpia, Geiger, Jonathan D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	De Gruyter 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070011/ https://www.ncbi.nlm.nih.gov/pubmed/37027339 http://dx.doi.org/10.1515/nipt-2022-0013

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