Late gene expression–deficient cytomegalovirus vectors elicit conventional T cells that do not protect against SIV

Rhesus cytomegalovirus–based (RhCMV-based) vaccine vectors induce immune responses that protect ~60% of rhesus macaques (RMs) from SIV(mac239) challenge. This efficacy depends on induction of effector memory–based (EM-biased) CD8(+) T cells recognizing SIV peptides presented by major histocompatibil...

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Detalles Bibliográficos
Autores principales: Hansen, Scott G., Womack, Jennie L., Perez, Wilma, Schmidt, Kimberli A., Marshall, Emily, Iyer, Ravi F., Cleveland Rubeor, Hillary, Otero, Claire E., Taher, Husam, Vande Burgt, Nathan H., Barfield, Richard, Randall, Kurt T., Morrow, David, Hughes, Colette M., Selseth, Andrea N., Gilbride, Roxanne M., Ford, Julia C., Caposio, Patrizia, Tarantal, Alice F., Chan, Cliburn, Malouli, Daniel, Barry, Peter A., Permar, Sallie R., Picker, Louis J., Früh, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070102/
https://www.ncbi.nlm.nih.gov/pubmed/36749635
http://dx.doi.org/10.1172/jci.insight.164692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070102/
https://www.ncbi.nlm.nih.gov/pubmed/36749635
http://dx.doi.org/10.1172/jci.insight.164692

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