Cargando…

Stabilization of E-cadherin adhesions by COX-2/GSK3β signaling is a targetable pathway in metastatic breast cancer

Metastatic progression of epithelial cancers can be associated with epithelial-mesenchymal transition (EMT) including transcriptional inhibition of E-cadherin (CDH1) expression. Recently, EM plasticity (EMP) and E-cadherin–mediated, cluster-based metastasis and treatment resistance have become more...

Descripción completa

Detalles Bibliográficos
Autores principales:	Balamurugan, Kuppusamy, Poria, Dipak K., Sehareen, Saadiya W., Krishnamurthy, Savitri, Tang, Wei, McKennett, Lois, Padmanaban, Veena, Czarra, Kelli, Ewald, Andrew J., Ueno, Naoto T., Ambs, Stefan, Sharan, Shikha, Sterneck, Esta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070121/ https://www.ncbi.nlm.nih.gov/pubmed/36757813 http://dx.doi.org/10.1172/jci.insight.156057

Ejemplares similares

The STAT3 inhibitor Stattic acts independently of STAT3 to decrease histone acetylation and modulate gene expression
por: Poria, Dipak K., et al.
Publicado: (2020)

Slug and E-Cadherin: Stealth Accomplices?
por: Sterneck, Esta, et al.
Publicado: (2020)

PERK signaling through C/EBPδ contributes to ER stress-induced expression of immunomodulatory and tumor promoting chemokines by cancer cells
por: Sheshadri, Namratha, et al.
Publicado: (2021)

The Many Faces of C/EBPδ and their Relevance for Inflammation and Cancer
por: Balamurugan, Kuppusamy, et al.
Publicado: (2013)

C/EBPδ links IL-6 and HIF-1 signaling to promote breast cancer stem cell-associated phenotypes
por: Balamurugan, Kuppusamy, et al.
Publicado: (2018)

FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4
por: Balamurugan, Kuppusamy, et al.
Publicado: (2013)

The C/EBPδ protein is stabilized by estrogen receptor α activity, inhibits SNAI2 expression, and associates with good prognosis in breast cancer
por: Mendoza-Villanueva, Daniel, et al.
Publicado: (2016)

The Cebpd (C/EBPδ) Gene Is Induced by Luteinizing Hormones in Ovarian Theca and Interstitial Cells But Is Not Essential for Mouse Ovary Function
por: Huang, A-Mei, et al.
Publicado: (2007)

Positional Variations in Mammary Gland Development and Cancer
por: Veltmaat, Jacqueline M., et al.
Publicado: (2013)

Between-tumor and within-tumor heterogeneity in invasive potential
por: Padmanaban, Veena, et al.
Publicado: (2020)

Transcription factor C/EBPβ isoform ratio regulates osteoclastogenesis through MafB
por: Smink, Jeske J, et al.
Publicado: (2009)

RNA-binding proteins La and HuR cooperatively modulate translation repression of PDCD4 mRNA
por: Kumar, Ravi, et al.
Publicado: (2020)

C/EBPδ protects from radiation-induced intestinal injury and sepsis by suppression of inflammatory and nitrosative stress
por: Banerjee, Sudip, et al.
Publicado: (2019)

E-cadherin is required for metastasis in multiple models of breast cancer
por: Padmanaban, Veena, et al.
Publicado: (2019)

Prognostic Significance of COX-2 Overexpression in BRAF-Mutated Middle Eastern Papillary Thyroid Carcinoma
por: Parvathareddy, Sandeep Kumar, et al.
Publicado: (2020)

Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer
por: Basudhar, Debashree, et al.
Publicado: (2017)

Multifocal Fixed Drug Eruption with COX-2 Inhibitor-Celecoxib
por: Chugh, Shikha, et al.
Publicado: (2013)

Inhibiting Janus Kinase 1 and BCL-2 to treat T cell acute lymphoblastic leukemia with IL7-Rα mutations
por: Senkevitch, Emilee, et al.
Publicado: (2018)

Anesthetic management of a patient with apical hypertrophic cardiomyopathy, a not so rare variant of hypertrophic cardiomyopathy
por: Ramachandran, Srinivasan, et al.
Publicado: (2023)

Development of a cyclometalated iridium complex with specific intramolecular hydrogen-bonding that acts as a fluorescent marker for the endoplasmic reticulum and causes photoinduced cell death
por: Mandal, Soumik, et al.
Publicado: (2014)

Hypoxia, partial EMT and collective migration: Emerging culprits in metastasis
por: Saxena, Kritika, et al.
Publicado: (2020)

Ultrasound guided fine needle aspiration biopsy of parathyroid gland and lesions
por: Dimashkieh, Haytham, et al.
Publicado: (2006)

Feasibility of using digital confocal microscopy for cytopathological examination in clinical practice
por: Krishnamurthy, Savitri, et al.
Publicado: (2021)

COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer
por: Glynn, Sharon A, et al.
Publicado: (2010)

Scientific Summary from the Morgan Welch MD Anderson Cancer Center Inflammatory Breast Cancer (IBC) Program 10(th) Anniversary Conference
por: Woodward, Wendy A., et al.
Publicado: (2017)

Interferon-gamma is quintessential for NOS2 and COX2 expression in ER(-) breast tumors that lead to poor outcome
por: Cheng, Robert Y. S., et al.
Publicado: (2023)

C/EBPδ Deficiency Sensitizes Mice to Ionizing Radiation-Induced Hematopoietic and Intestinal Injury
por: Pawar, Snehalata A., et al.
Publicado: (2014)

On the role of p53 in the cellular response to aneuploidy
por: Narkar, Akshay, et al.
Publicado: (2021)

Novel Reporter Alleles of GSK-3α and GSK-3β
por: Barrell, William B., et al.
Publicado: (2012)

Loss of oncogenic miR-155 in tumor cells promotes tumor growth by enhancing C/EBP-β-mediated MDSC infiltration
por: Kim, Sinae, et al.
Publicado: (2016)

Select Dietary Phytochemicals Function as Inhibitors of COX-1 but Not COX-2
por: Li, Haitao, et al.
Publicado: (2013)

Phytochemical mediated modulation of COX-3 and NFκB for the management and treatment of arthritis
por: Biswas, Dipak, et al.
Publicado: (2023)

Systemic Nos2 Depletion and Cox inhibition limits TNBC disease progression and alters lymphoid cell spatial orientation and density
por: Somasundaram, Veena, et al.
Publicado: (2022)

Sir James Coxe
Publicado: (1878)

Dr. Coxe, on Vaccination
por: Coxe, John Redman
Publicado: (1805)

Sir James Coxe
Publicado: (1878)

Dr. Joseph T. Cox
Publicado: (1918)

Bishop Coxe on Science
Publicado: (1869)

Cox-2: where are we in 2003? - Cardiovascular risk and Cox-2 inhibitors
por: Mukherjee, Debabrata, et al.
Publicado: (2003)

The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis
por: Lorenzi, Isotta, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_t97e9tuumfdivq7cve8iu25499