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The Multi-Faceted Consequences of NRF2 Activation throughout Carcinogenesis

The oxidative balance of a cell is maintained by the Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor 2 (NRF2) pathway. This cytoprotective pathway detoxifies reactive oxygen species and xenobiotics. The role of the KEAP1/NRF2 pathway as pro-tumorigenic or anti-t...

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Detalles Bibliográficos
Autores principales: Occhiuto, Christopher J., Moerland, Jessica A., Leal, Ana S., Gallo, Kathleen A., Liby, Karen T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070161/
https://www.ncbi.nlm.nih.gov/pubmed/36994476
http://dx.doi.org/10.14348/molcells.2023.2191