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Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis
Ribosomally synthesized and post-translationally modified peptide natural products have provided many highly unusual scaffolds. This includes the intriguing alkaloids crocagins, which possess a tetracyclic core structure and whose biosynthesis has remained enigmatic. Here we use in vitro experiments...
Autores principales: | Adam, Sebastian, Zheng, Dazhong, Klein, Andreas, Volz, Carsten, Mullen, William, Shirran, Sally L., Smith, Brian O., Kalinina, Olga V., Müller, Rolf, Koehnke, Jesko |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070186/ https://www.ncbi.nlm.nih.gov/pubmed/36894702 http://dx.doi.org/10.1038/s41557-023-01153-w |
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