Cargando…
Receptor clustering by a precise set of extracellular galectins initiates FGFR signaling
FGF/FGFR signaling is critical for the development and homeostasis of the human body and imbalanced FGF/FGFR contributes to the progression of severe diseases, including cancers. FGFRs are N-glycosylated, but the role of these modifications is largely unknown. Galectins are extracellular carbohydrat...
Autores principales: | Zukowska, Dominika, Gedaj, Aleksandra, Porebska, Natalia, Pozniak, Marta, Krzyscik, Mateusz, Czyrek, Aleksandra, Krowarsch, Daniel, Zakrzewska, Malgorzata, Otlewski, Jacek, Opalinski, Lukasz |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070233/ https://www.ncbi.nlm.nih.gov/pubmed/37012400 http://dx.doi.org/10.1007/s00018-023-04768-x |
Ejemplares similares
-
Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling
por: Gedaj, Aleksandra, et al.
Publicado: (2023) -
Correction: Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling
por: Gedaj, Aleksandra, et al.
Publicado: (2023) -
The Significance of Cell Surface N-Glycosylation for Internalization and Potency of Cytotoxic Conjugates Targeting Receptor Tyrosine Kinases
por: Poźniak, Marta, et al.
Publicado: (2022) -
N-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and nuclear envelope
por: Gregorczyk, Paulina, et al.
Publicado: (2023) -
Intrinsically Fluorescent Oligomeric Cytotoxic Conjugates
Toxic for FGFR1-Overproducing Cancers
por: Porębska, Natalia, et al.
Publicado: (2021)