Sub-millisecond conformational dynamics of the A(2A) adenosine receptor revealed by single-molecule FRET

The complex pharmacology of G-protein-coupled receptors (GPCRs) is defined by their multi-state conformational dynamics. Single-molecule Förster Resonance Energy Transfer (smFRET) is well suited to quantify dynamics for individual protein molecules; however, its application to GPCRs is challenging....

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Detalles Bibliográficos
Autores principales: Maslov, Ivan, Volkov, Oleksandr, Khorn, Polina, Orekhov, Philipp, Gusach, Anastasiia, Kuzmichev, Pavel, Gerasimov, Andrey, Luginina, Aleksandra, Coucke, Quinten, Bogorodskiy, Andrey, Gordeliy, Valentin, Wanninger, Simon, Barth, Anders, Mishin, Alexey, Hofkens, Johan, Cherezov, Vadim, Gensch, Thomas, Hendrix, Jelle, Borshchevskiy, Valentin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070357/
https://www.ncbi.nlm.nih.gov/pubmed/37012383
http://dx.doi.org/10.1038/s42003-023-04727-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070357/
https://www.ncbi.nlm.nih.gov/pubmed/37012383
http://dx.doi.org/10.1038/s42003-023-04727-z

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