Cargando…

MNT suppresses T cell apoptosis via BIM and is critical for T lymphomagenesis

The importance of c-MYC in regulating lymphopoiesis and promoting lymphomagenesis is well-established. Far less appreciated is the vital supporting role of MYC’s relative MNT. Using Rag1Cre-mediated Mnt deletion in lymphoid progenitor cells, we show here that, during normal T cell development, MNT l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Hai Vu, Vandenberg, Cassandra J., Robati, Mikara R., Ng, Ashley P., Cory, Suzanne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070419/ https://www.ncbi.nlm.nih.gov/pubmed/36755068 http://dx.doi.org/10.1038/s41418-023-01119-y

Ejemplares similares

Mnt modulates Myc-driven lymphomagenesis
por: Campbell, Kirsteen J, et al.
Publicado: (2017)

RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice
por: Delbridge, Alex R.D., et al.
Publicado: (2016)

Impact of elevated anti-apoptotic MCL-1 and BCL-2 on the development and treatment of MLL-AF9 AML in mice
por: Anstee, Natasha S., et al.
Publicado: (2018)

FoxO3 suppresses Myc-driven lymphomagenesis
por: Vandenberg, C J, et al.
Publicado: (2016)

Impact of loss of BH3-only proteins on the development and treatment of MLL-fusion gene-driven AML in mice
por: Bilardi, Rebecca A, et al.
Publicado: (2016)

Anti-apoptotic A1 is not essential for lymphoma development in Eµ-Myc mice but helps sustain transplanted Eµ-Myc tumour cells
por: Mensink, Mark, et al.
Publicado: (2018)

Loss of Bim Increases T Cell Production and Function in Interleukin 7 Receptor–deficient Mice
por: Pellegrini, Marc, et al.
Publicado: (2004)

MNT and Emerging Concepts of MNT-MYC Antagonism
por: Yang, Guang, et al.
Publicado: (2017)

MYC needs MNT
por: Link, Jason M., et al.
Publicado: (2013)

Biochemical characterization of recombinant Candida albicans mannosyltransferases Mnt1, Mnt2 and Mnt5 reveals new functions in O- and N-mannan biosynthesis
por: Díaz-Jiménez, Diana F., et al.
Publicado: (2012)

The Escherichia coli Small Protein MntS and Exporter MntP Optimize the Intracellular Concentration of Manganese
por: Martin, Julia E., et al.
Publicado: (2015)

Correction: The Escherichia coli Small Protein MntS and Exporter MntP Optimize the Intracellular Concentration of Manganese
Publicado: (2015)

Myc suppression of Nfkb2 accelerates lymphomagenesis
por: Keller, Ulrich, et al.
Publicado: (2010)

Manganese Detoxification by MntE Is Critical for Resistance to Oxidative Stress and Virulence of Staphylococcus aureus
por: Grunenwald, Caroline M., et al.
Publicado: (2019)

Immunosenescence and lymphomagenesis
por: Mancuso, Salvatrice, et al.
Publicado: (2018)

EBV and Lymphomagenesis
por: Sausen, Daniel G., et al.
Publicado: (2023)

Bim plays apoptosis offense
por: Powell, Kendall
Publicado: (2007)

Tax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression
por: Mühleisen, A, et al.
Publicado: (2014)

ECVAM retrospective validation of in vitro micronucleus test (MNT)
por: Corvi, Raffaella, et al.
Publicado: (2008)

The RAG2 C-terminus suppresses genomic instability and lymphomagenesis
por: Deriano, Ludovic, et al.
Publicado: (2011)

Virus-Associated Lymphomagenesis
por: Tarantul, V. Z.
Publicado: (2006)

BIM-mediated apoptosis and oncogene addiction
por: Li, Yulin, et al.
Publicado: (2016)

Loss of EMP2 Inhibits Melanogenesis of MNT1 Melanoma Cells via Regulation of TRP-2
por: Enkhtaivan, Enkhmend, et al.
Publicado: (2022)

FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway
por: Matsuzaki, Kenichiro, et al.
Publicado: (2015)

Induction of Melanogenesis by Rapamycin in Human MNT-1 Melanoma Cells
por: Hah, Young-Sool, et al.
Publicado: (2012)

The Multiple Faces of MNT and Its Role as a MYC Modulator
por: Liaño-Pons, Judit, et al.
Publicado: (2021)

Comprehensive and scalable quantification of splicing differences with MntJULiP
por: Yang, Guangyu, et al.
Publicado: (2022)

Lymphomagenesis predictors and related pathogenesis
por: Ruiz-Ordoñez, Ingrid, et al.
Publicado: (2021)

Insights about MYC and Apoptosis in B-Lymphomagenesis: An Update from Murine Models
por: Vecchio, Eleonora, et al.
Publicado: (2020)

Threonine 32 (Thr32) of FoxO3 is critical for TGF-β-induced apoptosis via Bim in hepatocarcinoma cells
por: Zhao, Xiangxuan, et al.
Publicado: (2014)

PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis
por: Mzoughi, Slim, et al.
Publicado: (2020)

A STING inhibitor suppresses EBV‐induced B cell transformation and lymphomagenesis
por: Miyagi, Shouhei, et al.
Publicado: (2021)

Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis
por: Tanaskovic, Nina, et al.
Publicado: (2022)

Differential effects of Vav‐promoter‐driven overexpression of BCLX and BFL1 on lymphocyte survival and B cell lymphomagenesis
por: Tuzlak, Selma, et al.
Publicado: (2018)

A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration
por: Hagenbuchner, Judith, et al.
Publicado: (2013)

POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim()()()()()
por: Wang, Chun-Hua, et al.
Publicado: (2018)

Abelson virus-induced lymphomagenesis in mice
Publicado: (1978)

HCV Infection and B-Cell Lymphomagenesis
por: Ito, Masahiko, et al.
Publicado: (2011)

Lymphoma and Lymphomagenesis in Primary Sjögren’s Syndrome
por: Alunno, Alessia, et al.
Publicado: (2018)

Role of MYC in B Cell Lymphomagenesis
por: Korać, Petra, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_149rtnmss8jfe548m5bhvf8cgi