Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer

Farrerol, a natural flavanone, promotes homologous recombination (HR) repair to improve genome-editing efficiency, but the specific protein that farrerol directly targets to regulate HR repair and the underlying molecular mechanisms have not been determined. Here, we find that the deubiquitinase UCH...

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Detalles Bibliográficos
Autores principales: Zhang, Weina, Wang, Mingzhu, Song, Zhiwei, Fu, Qianzheng, Chen, Jiayu, Zhang, Weitao, Gao, Shuai, Sun, Xiaoxiang, Yang, Guang, Zhang, Qiang, Yang, Jiaqing, Tang, Huanyin, Wang, Haiyan, Kou, Xiaochen, Wang, Hong, Mao, Zhiyong, Xu, Xiaojun, Gao, Shaorong, Jiang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070447/
https://www.ncbi.nlm.nih.gov/pubmed/37012254
http://dx.doi.org/10.1038/s41467-023-37576-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070447/
https://www.ncbi.nlm.nih.gov/pubmed/37012254
http://dx.doi.org/10.1038/s41467-023-37576-9

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