The p53 endoplasmic reticulum stress-response pathway evolved in humans but not in mice via PERK-regulated p53 mRNA structures

Cellular stress conditions activate p53-dependent pathways to counteract the inflicted damage. To achieve the required functional diversity, p53 is subjected to numerous post-translational modifications and the expression of isoforms. Little is yet known how p53 has evolved to respond to different s...

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Detalles Bibliográficos
Autores principales: Fusée, Leila, Salomao, Norman, Ponnuswamy, Anand, Wang, Lixiao, López, Ignacio, Chen, Sa, Gu, Xiaolian, Polyzoidis, Stavros, Vadivel Gnanasundram, Sivakumar, Fahraeus, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070458/
https://www.ncbi.nlm.nih.gov/pubmed/36813920
http://dx.doi.org/10.1038/s41418-023-01127-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070458/
https://www.ncbi.nlm.nih.gov/pubmed/36813920
http://dx.doi.org/10.1038/s41418-023-01127-y

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