Distinct transcriptomic and epigenomic modalities underpin human memory T cell subsets and their activation potential

Human memory T cells (MTC) are poised to rapidly respond to antigen re-exposure. Here, we derived the transcriptional and epigenetic programs of resting and ex vivo activated, circulating CD4(+) and CD8(+) MTC subsets. A progressive gradient of gene expression from naïve to T(CM) to T(EM) is observe...

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Detalles Bibliográficos
Autores principales: Rose, James R., Akdogan-Ozdilek, Bagdeser, Rahmberg, Andrew R., Powell, Michael D., Hicks, Sakeenah L., Scharer, Christopher D., Boss, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070634/
https://www.ncbi.nlm.nih.gov/pubmed/37012418
http://dx.doi.org/10.1038/s42003-023-04747-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070634/
https://www.ncbi.nlm.nih.gov/pubmed/37012418
http://dx.doi.org/10.1038/s42003-023-04747-9

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