CRISPR/Cas9-engineering of HMC-1.2 cells renders a human mast cell line with a single D816V-KIT mutation: An improved preclinical model for research on mastocytosis

The HMC-1.2 human mast cell (huMC) line is often employed in the study of attributes of neoplastic huMCs as found in patients with mastocytosis and their sensitivity to interventional drugs in vitro and in vivo. HMC-1.2 cells express constitutively active KIT, an essential growth factor receptor for...

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Detalles Bibliográficos
Autores principales: Bandara, Geethani, Falduto, Guido H., Luker, Andrea, Bai, Yun, Pfeiffer, Annika, Lack, Justin, Metcalfe, Dean D., Olivera, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071028/
https://www.ncbi.nlm.nih.gov/pubmed/37025992
http://dx.doi.org/10.3389/fimmu.2023.1078958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071028/
https://www.ncbi.nlm.nih.gov/pubmed/37025992
http://dx.doi.org/10.3389/fimmu.2023.1078958

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