Oncogenic TYK2 P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade

Tyrosine kinase 2 (TYK2) is a member of the Janus kinase/signal transducer and activator of transcription pathway, which is central in cytokine signaling. Previously, germline TYK2 mutations have been described in two patients developing de novo T-cell acute lymphoblastic leukemias (T-ALL) or precur...

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Detalles Bibliográficos
Autores principales: Woess, Katharina, Macho-Maschler, Sabine, van Ingen Schenau, Dorette S., Butler, Miriam, Lassnig, Caroline, Valcanover, Daniel, Poelzl, Andrea, Meissl, Katrin, Maurer, Barbara, Brandstoetter, Tania, Vogl, Claus, Koren, Anna, Kubicek, Stefan, Orlova, Anna, Moriggl, Richard, Strobl, Birgit, Sexl, Veronika, van Leeuwen, Frank N., Kuiper, Roland P., Mueller, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2022
Materias:
Article - Acute Lymphoblastic Leukemia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071116/
https://www.ncbi.nlm.nih.gov/pubmed/35021603
http://dx.doi.org/10.3324/haematol.2021.279848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071116/
https://www.ncbi.nlm.nih.gov/pubmed/35021603
http://dx.doi.org/10.3324/haematol.2021.279848

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