PDL1 shapes the classical Hodgkin lymphoma microenvironment without inducing T-cell exhaustion

Classical Hodgkin lymphoma (CHL) is unusually sensitive to PD1 inhibition and PDL1 is highly expressed on CHL cells and in the tumor microenvironment. This could be interpreted as evidence of exhaustion, but paradoxically, PD1(+) lymphocyte infiltration does not predict response to PD1 inhibitors an...

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Detalles Bibliográficos
Autores principales: Taylor, Joseph G., Truelove, Edward, Clear, Andrew, Calaminici, Maria, Gribben, John G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2022
Materias:
Article - Hodgkin Lymphoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071123/
https://www.ncbi.nlm.nih.gov/pubmed/35833296
http://dx.doi.org/10.3324/haematol.2022.280014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071123/
https://www.ncbi.nlm.nih.gov/pubmed/35833296
http://dx.doi.org/10.3324/haematol.2022.280014

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