Nucleophile responsive charge-reversing polycations for pDNA transfection

Polycationic carriers promise low cost and scalable gene therapy treatments, however inefficient intracellular unpacking of the genetic cargo has limited transfection efficiency. Charge-reversing polycations, which transition from cationic to neutral or negative charge, can offer targeted intracellu...

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Detalles Bibliográficos
Autores principales: Lewis, Reece W., Muralidharan, Aswin, Klemm, Benjamin, Boukany, Pouyan E., Eelkema, Rienk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071491/
https://www.ncbi.nlm.nih.gov/pubmed/37033743
http://dx.doi.org/10.1039/d3py00075c