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Conformation-dependent ligand hot spots in the spliceosomal RNA helicase BRR2
The conversion of hits to leads in drug discovery involves the elaboration of chemical core structures to increase their potency. In fragment-based drug discovery, low-molecular-weight compounds are tested for protein binding and are subsequently modified, with the tacit assumption that the binding...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071561/ https://www.ncbi.nlm.nih.gov/pubmed/36974964 http://dx.doi.org/10.1107/S2059798323001778 |