NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization

BACKGROUND: The NSD2 p.E1099K (EK) mutation is shown to be enriched in patients with relapsed acute lymphoblastic leukemia (ALL), indicating a role in clonal evolution and drug resistance. RESULTS: To uncover 3D chromatin architecture-related mechanisms underlying drug resistance, we perform Hi-C on...

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Detalles Bibliográficos
Autores principales: Narang, Sonali, Evensen, Nikki A., Saliba, Jason, Pierro, Joanna, Loh, Mignon L., Brown, Patrick A., Kolekar, Pandurang, Mulder, Heather, Shao, Ying, Easton, John, Ma, Xiaotu, Tsirigos, Aristotelis, Carroll, William L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071675/
https://www.ncbi.nlm.nih.gov/pubmed/37016431
http://dx.doi.org/10.1186/s13059-023-02905-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071675/
https://www.ncbi.nlm.nih.gov/pubmed/37016431
http://dx.doi.org/10.1186/s13059-023-02905-0

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