Safety, pharmacokinetics, and pharmacodynamics of SHR7280, an oral gonadotropin-releasing hormone receptor antagonist, in healthy men: a randomized, double-blind, placebo-controlled phase 1 study

BACKGROUND: Gonadotropin-releasing hormone (GnRH) antagonists are a promising therapeutic approach for treating hormone-dependent prostate cancer. Currently, the mainstream GnRH antagonists are polypeptide agents administered through subcutaneous injection. In this study, we evaluated the safety, ph...

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Detalles Bibliográficos
Autores principales: Li, Xin, Sun, Feifei, Zhang, Xiaolei, Lin, Pingping, Shen, Kai, Shen, Yu, Ma, Lingyu, Cao, Yu, Wang, Chenjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071678/
https://www.ncbi.nlm.nih.gov/pubmed/37013610
http://dx.doi.org/10.1186/s12916-023-02834-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071678/
https://www.ncbi.nlm.nih.gov/pubmed/37013610
http://dx.doi.org/10.1186/s12916-023-02834-6

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