Cargando…

APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly

BACKGROUND: Neuroinflammation, characterized by increased reactivity of microglia and astrocytes in the brain, is known to be present at various stages of the Alzheimer’s disease (AD) continuum. However, its presence and relationship with amyloid pathology in cognitively normal at-risk individuals i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Snellman, Anniina, Ekblad, Laura L., Tuisku, Jouni, Koivumäki, Mikko, Ashton, Nicholas J., Lantero-Rodriguez, Juan, Karikari, Thomas K., Helin, Semi, Bucci, Marco, Löyttyniemi, Eliisa, Parkkola, Riitta, Karrasch, Mira, Schöll, Michael, Zetterberg, Henrik, Blennow, Kaj, Rinne, Juha O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071691/ https://www.ncbi.nlm.nih.gov/pubmed/37016464 http://dx.doi.org/10.1186/s13195-023-01209-6

Ejemplares similares

Insulin resistance and body mass index are associated with TSPO PET in cognitively unimpaired elderly
por: Ekblad, Laura L, et al.
Publicado: (2023)

ASIC-E4: Interplay of Beta-Amyloid, Synaptic Density and Neuroinflammation in Cognitively Normal Volunteers With Three Levels of Genetic Risk for Late-Onset Alzheimer's Disease – Study Protocol and Baseline Characteristics
por: Snellman, Anniina, et al.
Publicado: (2022)

Association of Early β-Amyloid Accumulation and Neuroinflammation Measured With [(11)C]PBR28 in Elderly Individuals Without Dementia
por: Toppala, Sini, et al.
Publicado: (2021)

Associations of Fully Automated CSF and Novel Plasma Biomarkers With Alzheimer Disease Neuropathology at Autopsy
por: Grothe, Michel J., et al.
Publicado: (2021)

Adenosine A(2A) receptor availability in patients with early- and moderate-stage Parkinson’s disease
por: Waggan, Imran, et al.
Publicado: (2022)

Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer Disease
por: Moscoso, Alexis, et al.
Publicado: (2021)

Time course of phosphorylated-tau181 in blood across the Alzheimer’s disease spectrum
por: Moscoso, Alexis, et al.
Publicado: (2020)

Association of neuroinflammation with episodic memory: a [(11)C]PBR28 PET study in cognitively discordant twin pairs
por: Lindgren, Noora, et al.
Publicado: (2020)

Blood biomarkers and neurodegeneration in individuals exposed to repetitive head impacts
por: Bernick, Charles, et al.
Publicado: (2023)

Effects of pre‐analytical procedures on blood biomarkers for Alzheimer's pathophysiology, glial activation, and neurodegeneration
por: Ashton, Nicholas J., et al.
Publicado: (2021)

Association between polygenic risk score of Alzheimer’s disease and plasma phosphorylated tau in individuals from the Alzheimer’s Disease Neuroimaging Initiative
por: Zettergren, Anna, et al.
Publicado: (2021)

N-terminal and mid-region tau fragments as fluid biomarkers in neurological diseases
por: Snellman, Anniina, et al.
Publicado: (2022)

Midlife Insulin Resistance as a Predictor for Late-Life Cognitive Function and Cerebrovascular Lesions
por: Toppala, Sini, et al.
Publicado: (2019)

Evaluation of in vivo staging of amyloid deposition in cognitively unimpaired elderly aged 78–94
por: Michalowska, Malgorzata M., et al.
Publicado: (2022)

Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology
por: Ashton, Nicholas J., et al.
Publicado: (2021)

Editorial: Blood Biomarkers of Neurodegenerative Diseases
por: Karikari, Thomas K., et al.
Publicado: (2022)

Plasma NfL is associated with the APOE ε4 allele, brain imaging measurements of neurodegeneration, and lower recall memory scores in cognitively unimpaired late-middle-aged and older adults
por: Malek-Ahmadi, Michael, et al.
Publicado: (2023)

Truncating tau reveals different pathophysiological actions of oligomers in single neurons
por: Hill, Emily, et al.
Publicado: (2021)

Association of Cerebrovascular and Alzheimer Disease Biomarkers With Cholinergic White Matter Degeneration in Cognitively Unimpaired Individuals
por: Cedres, Nira, et al.
Publicado: (2022)

Striatal volume is related to phonemic verbal fluency but not to semantic or alternating verbal fluency in early Parkinson’s disease
por: Ellfolk, Ulla, et al.
Publicado: (2013)

Regional gray matter correlates of memory for emotion-laden words in middle-aged and older adults: A voxel-based morphometry study
por: Saarela, Carina, et al.
Publicado: (2017)

Plasma p-tau181 accurately predicts Alzheimer’s disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive decline
por: Lantero Rodriguez, Juan, et al.
Publicado: (2020)

Natalizumab treatment reduces microglial activation in the white matter of the MS brain
por: Sucksdorff, Marcus, et al.
Publicado: (2019)

Cognitive Effects of White Matter Pathology in Normal and Pathological Aging
por: Kaskikallio, Alar, et al.
Publicado: (2019)

Plasma biomarkers for Alzheimer’s Disease in relation to neuropathology and cognitive change
por: Smirnov, Denis S., et al.
Publicado: (2022)

P‐tau235: a novel biomarker for staging preclinical Alzheimer’s disease
por: Lantero‐Rodriguez, Juan, et al.
Publicado: (2021)

Clinical performance and head-to-head comparison of CSF p-tau235 with p-tau181, p-tau217 and p-tau231 in two memory clinic cohorts
por: Lantero-Rodriguez, Juan, et al.
Publicado: (2023)

Microglial activation, white matter tract damage, and disability in MS
por: Rissanen, Eero, et al.
Publicado: (2018)

A Non-APOE Polygenic Risk Score for Alzheimer’s Disease Is Associated With Cerebrospinal Fluid Neurofilament Light in a Representative Sample of Cognitively Unimpaired 70-Year Olds
por: Skoog, Ingmar, et al.
Publicado: (2021)

Plasma levels of phosphorylated tau 181 are associated with cerebral metabolic dysfunction in cognitively impaired and amyloid-positive individuals
por: Lussier, Firoza Z, et al.
Publicado: (2021)

Plasma biomarkers for neurodegenerative disorders: ready for prime time?
por: Balogun, Wasiu G., et al.
Publicado: (2023)

Tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta oscillations
por: Brown, Jessica, et al.
Publicado: (2023)

Midlife insulin resistance, APOE genotype, and late-life brain amyloid accumulation
por: Ekblad, Laura L., et al.
Publicado: (2018)

Biomarkers for tau pathology
por: Schöll, Michael, et al.
Publicado: (2019)

Head‐to‐head comparison of clinical performance of CSF phospho‐tau T181 and T217 biomarkers for Alzheimer's disease diagnosis
por: Karikari, Thomas K., et al.
Publicado: (2020)

Effects of White Matter Hyperintensities on Verbal Fluency in Healthy Older Adults and MCI/AD
por: Kaskikallio, Alar, et al.
Publicado: (2021)

Change in brain amyloid load and cognition in patients with amnestic mild cognitive impairment: a 3-year follow-up study
por: Rauhala, Elina, et al.
Publicado: (2022)

Retinal imaging demonstrates reduced capillary density in clinically unimpaired APOE ε4 gene carriers
por: Elahi, Fanny M., et al.
Publicado: (2021)

Memory precision of object-location binding is unimpaired in APOE ε4-carriers with spatial navigation deficits
por: Gellersen, Helena M, et al.
Publicado: (2021)

Spitting image: can saliva biomarkers reflect Alzheimer's disease?
por: Ashton, Nicholas J., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_s5iltc2gfl3p8nl93l29vu5jd6