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Crotonylation of GAPDH regulates human embryonic stem cell endodermal lineage differentiation and metabolic switch

BACKGROUND: Post-translational modifications of proteins are crucial to the regulation of their activity and function. As a newly discovered acylation modification, crotonylation of non-histone proteins remains largely unexplored, particularly in human embryonic stem cells (hESCs). METHODS: We inves...

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Detalles Bibliográficos
Autores principales: Zhang, Jingran, Shi, Guang, Pang, Junjie, Zhu, Xing, Feng, Qingcai, Na, Jie, Ma, Wenbin, Liu, Dan, Songyang, Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071711/
https://www.ncbi.nlm.nih.gov/pubmed/37013624
http://dx.doi.org/10.1186/s13287-023-03290-y