PARP1 negatively regulates MAPK signaling by impairing BRAF-X1 translation

In human cells BRAF oncogene is invariably expressed as a mix of two coding transcripts: BRAF-ref and BRAF-X1. These two mRNA isoforms, remarkably different in the sequence and length of their 3′UTRs, are potentially involved in distinct post-transcriptional regulatory circuits. Herein, we identify...

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Detalles Bibliográficos
Autores principales: Marranci, Andrea, Prantera, Antonella, Masotti, Simona, De Paolo, Raffaella, Baldanzi, Caterina, Podda, Maurizio S., Mero, Serena, Vitiello, Marianna, Franchin, Cinzia, Laezza, Mariavittoria, Comelli, Laura, Arrigoni, Giorgio, Cervelli, Tiziana, Del Pozzo, Giovanna, Poliseno, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071733/
https://www.ncbi.nlm.nih.gov/pubmed/37013641
http://dx.doi.org/10.1186/s13045-023-01428-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071733/
https://www.ncbi.nlm.nih.gov/pubmed/37013641
http://dx.doi.org/10.1186/s13045-023-01428-2

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