Monomeric crystal structure of the vaccine carrier protein CRM(197) and implications for vaccine development

CRM(197) is a genetically detoxified mutant of diphtheria toxin (DT) that is widely used as a carrier protein in conjugate vaccines. Protective immune responses to several bacterial diseases are obtained by coupling CRM(197) to glycans from these pathogens. Wild-type DT has been described in two oli...

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Detalles Bibliográficos
Autores principales: Gallagher, D. Travis, Oganesyan, Natalia, Lees, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2023
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071833/
https://www.ncbi.nlm.nih.gov/pubmed/36995122
http://dx.doi.org/10.1107/S2053230X23002364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071833/
https://www.ncbi.nlm.nih.gov/pubmed/36995122
http://dx.doi.org/10.1107/S2053230X23002364

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