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Monomeric crystal structure of the vaccine carrier protein CRM(197) and implications for vaccine development
CRM(197) is a genetically detoxified mutant of diphtheria toxin (DT) that is widely used as a carrier protein in conjugate vaccines. Protective immune responses to several bacterial diseases are obtained by coupling CRM(197) to glycans from these pathogens. Wild-type DT has been described in two oli...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071833/ https://www.ncbi.nlm.nih.gov/pubmed/36995122 http://dx.doi.org/10.1107/S2053230X23002364 |