A covalent inhibitor targeting the papain-like protease from SARS-CoV-2 inhibits viral replication

Covalent inhibitors of the papain-like protease (PLpro) from SARS-CoV-2 have great potential as antivirals, but their non-specific reactivity with thiols has limited their development. In this report, we performed an 8000 molecule electrophile screen against PLpro and identified an α-chloro amide fr...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Hesong, Gracia, Albert Vallejo, Røise, Joachim J., Boike, Lydia, Leon, Kristoffer, Schulze-Gahmen, Ursula, Stentzel, Michael R., Bajaj, Teena, Chen, Dake, Li, I.-Che, He, Maomao, Behrouzi, Kamyar, Khodabakhshi, Zahra, Nomura, Daniel K., Mofrad, Mohammad R. K., Kumar, G. Renuka, Ott, Melanie, Murthy, Niren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072198/
https://www.ncbi.nlm.nih.gov/pubmed/37025664
http://dx.doi.org/10.1039/d3ra00426k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072198/
https://www.ncbi.nlm.nih.gov/pubmed/37025664
http://dx.doi.org/10.1039/d3ra00426k

Ejemplares similares