Cargando…
A covalent inhibitor targeting the papain-like protease from SARS-CoV-2 inhibits viral replication
Covalent inhibitors of the papain-like protease (PLpro) from SARS-CoV-2 have great potential as antivirals, but their non-specific reactivity with thiols has limited their development. In this report, we performed an 8000 molecule electrophile screen against PLpro and identified an α-chloro amide fr...
Autores principales: | Han, Hesong, Gracia, Albert Vallejo, Røise, Joachim J., Boike, Lydia, Leon, Kristoffer, Schulze-Gahmen, Ursula, Stentzel, Michael R., Bajaj, Teena, Chen, Dake, Li, I.-Che, He, Maomao, Behrouzi, Kamyar, Khodabakhshi, Zahra, Nomura, Daniel K., Mofrad, Mohammad R. K., Kumar, G. Renuka, Ott, Melanie, Murthy, Niren |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072198/ https://www.ncbi.nlm.nih.gov/pubmed/37025664 http://dx.doi.org/10.1039/d3ra00426k |
Ejemplares similares
-
Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication
por: Bajaj, Teena, et al.
Publicado: (2023) -
Maltohexaose-indocyanine green (MH-ICG) for near infrared imaging of endocarditis
por: Takemiya, Kiyoko, et al.
Publicado: (2021) -
Repurposing Known Drugs as Covalent and Non-covalent Inhibitors of the SARS-CoV-2 Papain-Like Protease
por: Delre, Pietro, et al.
Publicado: (2020) -
Advances in covalent drug discovery
por: Boike, Lydia, et al.
Publicado: (2022) -
A traceless linker for aliphatic amines that rapidly and quantitatively fragments after reduction
por: He, Maomao, et al.
Publicado: (2020)