Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouse

Understanding the molecular mechanisms that lead to birth defects is an important step towards improved primary prevention. Mouse embryos homozygous for the Kumba (Ku) mutant allele of Zic2 develop severe spina bifida with complete lack of dorsolateral hinge points (DLHPs) in the neuroepithelium. Bo...

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Detalles Bibliográficos
Autores principales: Escuin, Sarah, Rose Raza-Knight, Saba, Savery, Dawn, Gaston-Massuet, Carles, Galea, Gabriel L., Greene, Nicholas D. E., Copp, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073009/
https://www.ncbi.nlm.nih.gov/pubmed/36916392
http://dx.doi.org/10.1242/dmm.049858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073009/
https://www.ncbi.nlm.nih.gov/pubmed/36916392
http://dx.doi.org/10.1242/dmm.049858

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