Synthesis, cytotoxicity, and pharmacokinetic evaluations of niclosamide analogs for anti-SARS-CoV-2

Niclosamide, an oral anthelmintic drug, could inhibit SARS-CoV-2 virus replication through autophagy induction, but high cytotoxicity and poor oral bioavailability limited its application. Twenty-three niclosamide analogs were designed and synthesized, of which compound 21 was found to exhibit the b...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Rui, Zhang, Zherui, Huang, Shuhong, Peng, Ke, Jiang, Hualiang, Shen, Jingshan, Zhang, Bo, Jiang, Xiangrui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Masson SAS. 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073089/
https://www.ncbi.nlm.nih.gov/pubmed/37058956
http://dx.doi.org/10.1016/j.ejmech.2023.115320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073089/
https://www.ncbi.nlm.nih.gov/pubmed/37058956
http://dx.doi.org/10.1016/j.ejmech.2023.115320

Ejemplares similares