Single-molecule fingerprinting of protein-drug interaction using a funneled biological nanopore

In drug discovery, efficient screening of protein-drug interactions (PDIs) is hampered by the limitations of current biophysical approaches. Here, we develop a biological nanopore sensor for single-molecule detection of proteins and PDIs using the pore-forming toxin YaxAB. Using this YaxAB nanopore,...

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Detalles Bibliográficos
Autores principales: Jeong, Ki-Baek, Ryu, Minju, Kim, Jin-Sik, Kim, Minsoo, Yoo, Jejoong, Chung, Minji, Oh, Sohee, Jo, Gyunghee, Lee, Seong-Gyu, Kim, Ho Min, Lee, Mi-Kyung, Chi, Seung-Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073129/
https://www.ncbi.nlm.nih.gov/pubmed/37015934
http://dx.doi.org/10.1038/s41467-023-37098-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073129/
https://www.ncbi.nlm.nih.gov/pubmed/37015934
http://dx.doi.org/10.1038/s41467-023-37098-4

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