Mesenchymal stem cell-derived extracellular vesicles subvert Th17 cells by destabilizing RORγt through posttranslational modification

Mesenchymal stem cell (MSC)-derived small extracellular vesicles (MSC-sEVs) are known to exert immunosuppressive functions. This study showed that MSC-sEVs specifically convert T helper 17 (Th17) cells into IL-17 low-producer (ex-Th17) cells by degrading RAR-related orphan receptor γt (RORγt) at the...

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Detalles Bibliográficos
Autores principales: Jung, Sunyoung, Lee, Sunho, Kim, Hyun Je, Kim, Sueon, Moon, Ji Hwan, Chung, Hyunwoo, Kang, Seong-Jun, Park, Chung-Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073130/
https://www.ncbi.nlm.nih.gov/pubmed/36964252
http://dx.doi.org/10.1038/s12276-023-00949-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073130/
https://www.ncbi.nlm.nih.gov/pubmed/36964252
http://dx.doi.org/10.1038/s12276-023-00949-7

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