Cargando…

The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: classification, mechanisms, and potential therapeutic implications

N6-methyladenosine (m6A) is one of the epigenetic modifications of RNA. The addition of this chemical mark to RNA molecules regulates gene expression by affecting the fate of the RNA molecules. This posttranscriptional RNA modification is reversible and regulated by methyltransferase “writers” and d...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Ziying, Gao, Lei, Cheng, Long, Lv, Gaoyuan, Sun, Bei, Wang, Gang, Tang, Qiushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073155/
https://www.ncbi.nlm.nih.gov/pubmed/36854773
http://dx.doi.org/10.1038/s12276-023-00944-y
_version_ 1785019530382147584
author Liu, Ziying
Gao, Lei
Cheng, Long
Lv, Gaoyuan
Sun, Bei
Wang, Gang
Tang, Qiushi
author_facet Liu, Ziying
Gao, Lei
Cheng, Long
Lv, Gaoyuan
Sun, Bei
Wang, Gang
Tang, Qiushi
author_sort Liu, Ziying
collection PubMed
description N6-methyladenosine (m6A) is one of the epigenetic modifications of RNA. The addition of this chemical mark to RNA molecules regulates gene expression by affecting the fate of the RNA molecules. This posttranscriptional RNA modification is reversible and regulated by methyltransferase “writers” and demethylase “erasers”. The fate of m6A-modified RNAs depends on the function of different “readers” that recognize and bind to them. Research on m6A methylation modification has recently increased due to its important role in regulating cancer progression. Noncoding RNAs (ncRNAs) are a class of RNA molecules that are transcribed from the genome but whose roles have been overlooked due to their lack of well-defined potential for translation into proteins or peptides. However, this misconception has now been completely overturned. ncRNAs regulate various diseases, especially tumors, and it has been confirmed that they play either tumor-promoting or tumor-suppressing roles in almost all types of tumors. In this review, we discuss the m6A modification of different types of ncRNA and summarize the mechanisms involved. Finally, we discuss the progress of research on clinical treatment and discuss the important significance of the m6A modification of ncRNAs in the clinical treatment of tumors.
format Online
Article
Text
id pubmed-10073155
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-100731552023-04-06 The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: classification, mechanisms, and potential therapeutic implications Liu, Ziying Gao, Lei Cheng, Long Lv, Gaoyuan Sun, Bei Wang, Gang Tang, Qiushi Exp Mol Med Review Article N6-methyladenosine (m6A) is one of the epigenetic modifications of RNA. The addition of this chemical mark to RNA molecules regulates gene expression by affecting the fate of the RNA molecules. This posttranscriptional RNA modification is reversible and regulated by methyltransferase “writers” and demethylase “erasers”. The fate of m6A-modified RNAs depends on the function of different “readers” that recognize and bind to them. Research on m6A methylation modification has recently increased due to its important role in regulating cancer progression. Noncoding RNAs (ncRNAs) are a class of RNA molecules that are transcribed from the genome but whose roles have been overlooked due to their lack of well-defined potential for translation into proteins or peptides. However, this misconception has now been completely overturned. ncRNAs regulate various diseases, especially tumors, and it has been confirmed that they play either tumor-promoting or tumor-suppressing roles in almost all types of tumors. In this review, we discuss the m6A modification of different types of ncRNA and summarize the mechanisms involved. Finally, we discuss the progress of research on clinical treatment and discuss the important significance of the m6A modification of ncRNAs in the clinical treatment of tumors. Nature Publishing Group UK 2023-03-01 /pmc/articles/PMC10073155/ /pubmed/36854773 http://dx.doi.org/10.1038/s12276-023-00944-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Liu, Ziying
Gao, Lei
Cheng, Long
Lv, Gaoyuan
Sun, Bei
Wang, Gang
Tang, Qiushi
The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: classification, mechanisms, and potential therapeutic implications
title The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: classification, mechanisms, and potential therapeutic implications
title_full The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: classification, mechanisms, and potential therapeutic implications
title_fullStr The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: classification, mechanisms, and potential therapeutic implications
title_full_unstemmed The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: classification, mechanisms, and potential therapeutic implications
title_short The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: classification, mechanisms, and potential therapeutic implications
title_sort roles of n6-methyladenosine and its target regulatory noncoding rnas in tumors: classification, mechanisms, and potential therapeutic implications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073155/
https://www.ncbi.nlm.nih.gov/pubmed/36854773
http://dx.doi.org/10.1038/s12276-023-00944-y
work_keys_str_mv AT liuziying therolesofn6methyladenosineanditstargetregulatorynoncodingrnasintumorsclassificationmechanismsandpotentialtherapeuticimplications
AT gaolei therolesofn6methyladenosineanditstargetregulatorynoncodingrnasintumorsclassificationmechanismsandpotentialtherapeuticimplications
AT chenglong therolesofn6methyladenosineanditstargetregulatorynoncodingrnasintumorsclassificationmechanismsandpotentialtherapeuticimplications
AT lvgaoyuan therolesofn6methyladenosineanditstargetregulatorynoncodingrnasintumorsclassificationmechanismsandpotentialtherapeuticimplications
AT sunbei therolesofn6methyladenosineanditstargetregulatorynoncodingrnasintumorsclassificationmechanismsandpotentialtherapeuticimplications
AT wanggang therolesofn6methyladenosineanditstargetregulatorynoncodingrnasintumorsclassificationmechanismsandpotentialtherapeuticimplications
AT tangqiushi therolesofn6methyladenosineanditstargetregulatorynoncodingrnasintumorsclassificationmechanismsandpotentialtherapeuticimplications
AT liuziying rolesofn6methyladenosineanditstargetregulatorynoncodingrnasintumorsclassificationmechanismsandpotentialtherapeuticimplications
AT gaolei rolesofn6methyladenosineanditstargetregulatorynoncodingrnasintumorsclassificationmechanismsandpotentialtherapeuticimplications
AT chenglong rolesofn6methyladenosineanditstargetregulatorynoncodingrnasintumorsclassificationmechanismsandpotentialtherapeuticimplications
AT lvgaoyuan rolesofn6methyladenosineanditstargetregulatorynoncodingrnasintumorsclassificationmechanismsandpotentialtherapeuticimplications
AT sunbei rolesofn6methyladenosineanditstargetregulatorynoncodingrnasintumorsclassificationmechanismsandpotentialtherapeuticimplications
AT wanggang rolesofn6methyladenosineanditstargetregulatorynoncodingrnasintumorsclassificationmechanismsandpotentialtherapeuticimplications
AT tangqiushi rolesofn6methyladenosineanditstargetregulatorynoncodingrnasintumorsclassificationmechanismsandpotentialtherapeuticimplications