Targeting the BRCA1/2 deficient cancer with PARP inhibitors: Clinical outcomes and mechanistic insights

BRCA1 and BRCA2 play a critical role in a variety of molecular processes related to DNA metabolism, including homologous recombination and mediating the replication stress response. Individuals with mutations in the BRCA1 and BRCA2 (BRCA1/2) genes have a significantly higher risk of developing vario...

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Detalles Bibliográficos
Autores principales: Ragupathi, Ashwin, Singh, Manrose, Perez, Alexis M., Zhang, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073599/
https://www.ncbi.nlm.nih.gov/pubmed/37035242
http://dx.doi.org/10.3389/fcell.2023.1133472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073599/
https://www.ncbi.nlm.nih.gov/pubmed/37035242
http://dx.doi.org/10.3389/fcell.2023.1133472

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