Immune transgene-dependent myocarditis in macaques after systemic administration of adeno-associated virus expressing human acid alpha-glucosidase

Immune responses to human non-self transgenes can present challenges in preclinical studies of adeno-associated virus (AAV) gene therapy candidates in nonhuman primates. Although anti-transgene immune responses are usually mild and non-adverse, they can confound pharmacological readouts and complica...

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Detalles Bibliográficos
Autores principales: Hordeaux, Juliette, Ramezani, Ali, Tuske, Steve, Mehta, Nickita, Song, Chunjuan, Lynch, Anna, Lupino, Katherine, Chichester, Jessica A., Buza, Elizabeth L., Dyer, Cecilia, Yu, Hongwei, Bell, Peter, Weimer, Jill M., Do, Hung, Wilson, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073725/
https://www.ncbi.nlm.nih.gov/pubmed/37033976
http://dx.doi.org/10.3389/fimmu.2023.1094279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073725/
https://www.ncbi.nlm.nih.gov/pubmed/37033976
http://dx.doi.org/10.3389/fimmu.2023.1094279

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