Inferring transcriptional bursting kinetics from single-cell snapshot data using a generalized telegraph model

Gene expression has inherent stochasticity resulting from transcription's burst manners. Single-cell snapshot data can be exploited to rigorously infer transcriptional burst kinetics, using mathematical models as blueprints. The classical telegraph model (CTM) has been widely used to explain tr...

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Detalles Bibliográficos
Autores principales: Luo, Songhao, Zhang, Zhenquan, Wang, Zihao, Yang, Xiyan, Chen, Xiaoxuan, Zhou, Tianshou, Zhang, Jiajun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2023
Materias:
Biochemistry, Cellular and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073913/
https://www.ncbi.nlm.nih.gov/pubmed/37035293
http://dx.doi.org/10.1098/rsos.221057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073913/
https://www.ncbi.nlm.nih.gov/pubmed/37035293
http://dx.doi.org/10.1098/rsos.221057

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