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Inferring transcriptional bursting kinetics from single-cell snapshot data using a generalized telegraph model
Gene expression has inherent stochasticity resulting from transcription's burst manners. Single-cell snapshot data can be exploited to rigorously infer transcriptional burst kinetics, using mathematical models as blueprints. The classical telegraph model (CTM) has been widely used to explain tr...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073913/ https://www.ncbi.nlm.nih.gov/pubmed/37035293 http://dx.doi.org/10.1098/rsos.221057 |