Risk of antidepressant initiation among users of cardiovascular agents and metformin.: Findings from the Trøndelag Health Study (HUNT) and Norwegian Prescription Database (NorPD), Norway
Cardiovascular disease and diabetes are risk factors for depression, yet the relationship between the drug treatments for these diseases and the risk of antidepressant initiation remains unclear. This study aimed to examine possible associations between the use of angiotensin II receptor blockers (A...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073930/ https://www.ncbi.nlm.nih.gov/pubmed/37016811 http://dx.doi.org/10.1002/prp2.1078 |
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author | Bojanić, Ivana Bjerkeset, Ottar Williams, Lana J. Berk, Michael Bjørngaard, Johan Håkon Sund, Erik R. Sletvold, Hege |
author_facet | Bojanić, Ivana Bjerkeset, Ottar Williams, Lana J. Berk, Michael Bjørngaard, Johan Håkon Sund, Erik R. Sletvold, Hege |
author_sort | Bojanić, Ivana |
collection | PubMed |
description | Cardiovascular disease and diabetes are risk factors for depression, yet the relationship between the drug treatments for these diseases and the risk of antidepressant initiation remains unclear. This study aimed to examine possible associations between the use of angiotensin II receptor blockers (ARBs), angiotensin‐converting enzyme inhibitors (ACEI), acetylsalicylic acid (ASA), beta‐blockers (BB), calcium channel blockers (CCB), diuretics, or metformin and risk of antidepressant initiation. The Trøndelag Health Study (HUNT3), Norway, was linked to the Norwegian Prescription Database (NorPD). Participants with no prescriptions of cardiovascular agents, metformin, or antidepressants for at least 6 months before HUNT3 (baseline) were eligible and followed for 10 years. The exposure was the use of cardiovascular agents or metformin, defined as mono‐ or polytherapy from baseline to end of follow‐up. The outcome was the initiation of antidepressant use, indicated by the first drug dispensation during the study period and expressed as hazard ratios (HRs) with 95% confidence intervals (CI). Among 20 227 adults aged 40–70 years at baseline, we observed different associations between cardiovascular agents or metformin and the risk of antidepressant initiation. ARBs or CCB monotherapy was associated with a lower risk of initiating antidepressant use (HR 0.70; 95%CI 0.56–0.88 and HR 0.81; 95%CI 0.61–1.06, respectively) compared to no use of any drugs included in the study (reference). Reduced risk of antidepressant initiation was among ASA or statin polytherapy users, whereas there was a small increased risk among participants on ASA monotherapy. In contrast, there was no statistical evidence of associations between ACEI, BB, diuretics, or metformin and increased or decreased risk of antidepressant initiation. Our mixed findings indicate the possibility that some cardiovascular agents may be associated with a reduced risk of initiating antidepressant use while others may not. However, bias due to the limitations of the study design is possible. |
format | Online Article Text |
id | pubmed-10073930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100739302023-04-06 Risk of antidepressant initiation among users of cardiovascular agents and metformin.: Findings from the Trøndelag Health Study (HUNT) and Norwegian Prescription Database (NorPD), Norway Bojanić, Ivana Bjerkeset, Ottar Williams, Lana J. Berk, Michael Bjørngaard, Johan Håkon Sund, Erik R. Sletvold, Hege Pharmacol Res Perspect Original Articles Cardiovascular disease and diabetes are risk factors for depression, yet the relationship between the drug treatments for these diseases and the risk of antidepressant initiation remains unclear. This study aimed to examine possible associations between the use of angiotensin II receptor blockers (ARBs), angiotensin‐converting enzyme inhibitors (ACEI), acetylsalicylic acid (ASA), beta‐blockers (BB), calcium channel blockers (CCB), diuretics, or metformin and risk of antidepressant initiation. The Trøndelag Health Study (HUNT3), Norway, was linked to the Norwegian Prescription Database (NorPD). Participants with no prescriptions of cardiovascular agents, metformin, or antidepressants for at least 6 months before HUNT3 (baseline) were eligible and followed for 10 years. The exposure was the use of cardiovascular agents or metformin, defined as mono‐ or polytherapy from baseline to end of follow‐up. The outcome was the initiation of antidepressant use, indicated by the first drug dispensation during the study period and expressed as hazard ratios (HRs) with 95% confidence intervals (CI). Among 20 227 adults aged 40–70 years at baseline, we observed different associations between cardiovascular agents or metformin and the risk of antidepressant initiation. ARBs or CCB monotherapy was associated with a lower risk of initiating antidepressant use (HR 0.70; 95%CI 0.56–0.88 and HR 0.81; 95%CI 0.61–1.06, respectively) compared to no use of any drugs included in the study (reference). Reduced risk of antidepressant initiation was among ASA or statin polytherapy users, whereas there was a small increased risk among participants on ASA monotherapy. In contrast, there was no statistical evidence of associations between ACEI, BB, diuretics, or metformin and increased or decreased risk of antidepressant initiation. Our mixed findings indicate the possibility that some cardiovascular agents may be associated with a reduced risk of initiating antidepressant use while others may not. However, bias due to the limitations of the study design is possible. John Wiley and Sons Inc. 2023-04-04 /pmc/articles/PMC10073930/ /pubmed/37016811 http://dx.doi.org/10.1002/prp2.1078 Text en © 2023 The Authors. Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Bojanić, Ivana Bjerkeset, Ottar Williams, Lana J. Berk, Michael Bjørngaard, Johan Håkon Sund, Erik R. Sletvold, Hege Risk of antidepressant initiation among users of cardiovascular agents and metformin.: Findings from the Trøndelag Health Study (HUNT) and Norwegian Prescription Database (NorPD), Norway |
title | Risk of antidepressant initiation among users of cardiovascular agents and metformin.: Findings from the Trøndelag Health Study (HUNT) and Norwegian Prescription Database (NorPD), Norway |
title_full | Risk of antidepressant initiation among users of cardiovascular agents and metformin.: Findings from the Trøndelag Health Study (HUNT) and Norwegian Prescription Database (NorPD), Norway |
title_fullStr | Risk of antidepressant initiation among users of cardiovascular agents and metformin.: Findings from the Trøndelag Health Study (HUNT) and Norwegian Prescription Database (NorPD), Norway |
title_full_unstemmed | Risk of antidepressant initiation among users of cardiovascular agents and metformin.: Findings from the Trøndelag Health Study (HUNT) and Norwegian Prescription Database (NorPD), Norway |
title_short | Risk of antidepressant initiation among users of cardiovascular agents and metformin.: Findings from the Trøndelag Health Study (HUNT) and Norwegian Prescription Database (NorPD), Norway |
title_sort | risk of antidepressant initiation among users of cardiovascular agents and metformin.: findings from the trøndelag health study (hunt) and norwegian prescription database (norpd), norway |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073930/ https://www.ncbi.nlm.nih.gov/pubmed/37016811 http://dx.doi.org/10.1002/prp2.1078 |
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