Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy

Polycomb repressive complex 1 (PRC1) is an essential epigenetic regulator that mainly controls histone H2A Lys119 mono‐ubiquitination (H2AK119ub). B cell‐specific Moloney murine leukemia virus Integration site 1 (BMI1) and really interesting new gene 1B (RING1B) are PRC1 core components and play cri...

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Detalles Bibliográficos
Autores principales: Park, Kwang‐Su, Qin, Lihuai, Kabir, Md, Luo, Kaixiu, Dale, Brandon, Zhong, Yue, Kim, Arum, Wang, Gang Greg, Kaniskan, Husnu Ümit, Jin, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074066/
https://www.ncbi.nlm.nih.gov/pubmed/36737841
http://dx.doi.org/10.1002/advs.202205573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074066/
https://www.ncbi.nlm.nih.gov/pubmed/36737841
http://dx.doi.org/10.1002/advs.202205573

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