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PlGF/FLT-1 deficiency leads to reduced STAT3-C/EBPβ signaling and aberrant polarization in decidual macrophages during early spontaneous abortion

INTRODUCTION: Dysregulated macrophage polarization (excessive M1-like or limited M2-like macrophages) in the early decidua contributes to allogeneic fetal rejection and thus early spontaneous abortion. However, the modulators of M1/M2 balance at the early maternal-fetal interface remain mostly unkno...

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Detalles Bibliográficos
Autores principales: Chang, Ruiqi, Dai, Jingcong, Wang, Li, Liu, Hao, Jiang, Huanhuan, Liu, Xiaoyu, Jiang, Linying, He, Fan, Hu, Lina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074254/
https://www.ncbi.nlm.nih.gov/pubmed/37033974
http://dx.doi.org/10.3389/fimmu.2023.1061949