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Semisynthesis reveals apoptin as a tumour-selective protein prodrug that causes cytoskeletal collapse

Apoptin is a small viral protein capable of inducing cell death selectively in cancer cells. Despite its potential as an anticancer agent, relatively little is known about its mechanism of toxicity and cancer-selectivity. Previous experiments suggest that cancer-selective phosphorylation modulates a...

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Detalles Bibliográficos
Autores principales: Wyatt, Jasmine, Chan, Yuen Ka, Hess, Mateusz, Tavassoli, Mahvash, Müller, Manuel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074440/
https://www.ncbi.nlm.nih.gov/pubmed/37035694
http://dx.doi.org/10.1039/d2sc04481a