Cargando…

Paired protein kinases PRKCI-RIPK2 promote pancreatic cancer growth and metastasis via enhancing NF-κB/JNK/ERK phosphorylation

BACKGROUND: Protein kinases play a pivotal role in the malignant evolution of pancreatic cancer (PC) through mediating phosphorylation. Many kinase inhibitors have been developed and translated into clinical use, while the complex pathology of PC confounds their clinical efficacy and warrants the di...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiao, Juying, Ruan, Linjie, Cheng, Chien-shan, Wang, Fengjiao, Yang, Peiwen, Chen, Zhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074657/ https://www.ncbi.nlm.nih.gov/pubmed/37016317 http://dx.doi.org/10.1186/s10020-023-00648-z

Ejemplares similares

In Vivo Conditions to Identify Prkci Phosphorylation Targets Using the Analog-Sensitive Kinase Method in Zebrafish
por: Cibrián Uhalte, Elena, et al.
Publicado: (2012)

Role and mechanism of circ-PRKCI in hepatocellular carcinoma
por: Qi, Su-Xia, et al.
Publicado: (2019)

PRKCI promotes immune suppression in ovarian cancer
por: Sarkar, Sharmistha, et al.
Publicado: (2017)

Prkci Regulates Autophagy and Pancreatic Tumorigenesis in Mice
por: Inman, Kristin S., et al.
Publicado: (2022)

A Mouse Model of Damp-Heat Syndrome in Traditional Chinese Medicine and Its Impact on Pancreatic Tumor Growth
por: Jiao, Juying, et al.
Publicado: (2022)

Impact of deleterious missense PRKCI variants on structural and functional dynamics of protein
por: Shah, Hania, et al.
Publicado: (2022)

Parkin regulates NF-κB by mediating site-specific ubiquitination of RIPK1
por: Wang, Yu, et al.
Publicado: (2018)

TLRs, NF-κB, JNK, and Liver Regeneration
por: Iimuro, Yuji, et al.
Publicado: (2010)

RIPK4 Suppresses the Invasion and Metastasis of Hepatocellular Carcinoma by Inhibiting the Phosphorylation of STAT3
por: Li, Haoran, et al.
Publicado: (2021)

LncRNA LINC01537 Promotes Gastric Cancer Metastasis and Tumorigenesis by Stabilizing RIPK4 to Activate NF-κB Signaling
por: Zhong, Guang-Yu, et al.
Publicado: (2022)

Sildenafil improves radiation‐induced oral mucositis by attenuating oxidative stress, NF‐κB, ERK and JNK signalling pathways
por: Ala, Moein, et al.
Publicado: (2022)

PRKCI Mediates Radiosensitivity via the Hedgehog/GLI1 Pathway in Cervical Cancer
por: Wu, Zhuna, et al.
Publicado: (2022)

NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation
por: Kumari, Snehlata, et al.
Publicado: (2021)

NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis
por: Maeda, Shin
Publicado: (2010)

Type 2 Diabetes Is Associated with Altered NF-κB DNA Binding Activity, JNK Phosphorylation, and AMPK Phosphorylation in Skeletal Muscle after LPS
por: Andreasen, Anne Sofie, et al.
Publicado: (2011)

Magnoliae flos Downregulated Lipopolysaccharide-Induced Inflammatory Responses via NF-κB/ERK-JNK MAPK/STAT3 Pathways
por: Gil, Tae-Young, et al.
Publicado: (2022)

Aromadendrin Inhibits Lipopolysaccharide-Induced Nuclear Translocation of NF-κB and Phosphorylation of JNK in RAW 264.7 Macrophage Cells
por: Lee, Jae-Won, et al.
Publicado: (2013)

Circular RNA PRKCI promotes glioma cell progression by inhibiting microRNA-545
por: Zhang, Xuebang, et al.
Publicado: (2019)

Investigation of UTR Variants by Computational Approaches Reveal Their Functional Significance in PRKCI Gene Regulation
por: Shah, Hania, et al.
Publicado: (2023)

5-Iodotubercidin sensitizes cells to RIPK1-dependent necroptosis by interfering with NFκB signaling
por: Chauhan, Chanchal, et al.
Publicado: (2023)

Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells
por: Jia, Yan, et al.
Publicado: (2018)

miR-129-5p targets Wnt5a to block PKC/ERK/NF-κB and JNK pathways in glioblastoma
por: Zeng, Ailiang, et al.
Publicado: (2018)

Farrerol Ameliorates TNBS-Induced Colonic Inflammation by Inhibiting ERK1/2, JNK1/2, and NF-κB Signaling Pathway
por: Ran, Xin, et al.
Publicado: (2018)

IL-8 promotes inflammatory mediators and stimulates activation of p38 MAPK/ERK-NF-κB pathway and reduction of JNK in HNSCC
por: Chan, Leong-Perng, et al.
Publicado: (2017)

Alternative promotion and suppression of metastasis by JNK2 governed by its phosphorylation
por: Hu, Sike, et al.
Publicado: (2017)

Inhibition of RIPK1-dependent regulated acinar cell necrosis provides protection against acute pancreatitis via the RIPK1/NF-κB/AQP8 pathway
por: Duan, Peng-yu, et al.
Publicado: (2019)

RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation
por: Wong, Jerry, et al.
Publicado: (2019)

The Regulation of NF-κB Subunits by Phosphorylation
por: Christian, Frank, et al.
Publicado: (2016)

Baicalin Liposome Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Inhibiting TLR4/JNK/ERK/NF-κB Pathway
por: Long, Yu, et al.
Publicado: (2020)

Camel Milk Mitigates Cyclosporine-Induced Renal Damage in Rats: Targeting p38/ERK/JNK MAPKs, NF-κB, and Matrix Metalloproteinases
por: Arab, Hany H., et al.
Publicado: (2021)

Bushen huoxue decoction inhibits RANKL-stimulated osteoclastogenesis and glucocorticoid-induced bone loss by modulating the NF-κB, ERK, and JNK signaling pathways
por: Liu, Yamei, et al.
Publicado: (2022)

Genomic locus proteomic screening identifies the NF-κB signaling pathway components NFκB1 and IKBKG as transcriptional regulators of Ripk3 in endothelial cells
por: Gao, Siqi, et al.
Publicado: (2021)

Integrated genomic analysis of clear cell ovarian cancers identified PRKCI as a potential therapeutic target
por: Tsang, Tsun Yee, et al.
Publicado: (2017)

Inhibition of RIPK1 by ZJU-37 promotes oligodendrocyte progenitor proliferation and remyelination via NF-κB pathway
por: Ma, Xiao-Ru, et al.
Publicado: (2022)

Dengue virus downregulates TNFR1- and TLR3-stimulated NF-κB activation by targeting RIPK1
por: Udawatte, Darshika J., et al.
Publicado: (2022)

Anti-Inflammatory Effects of Cumin Essential Oil by Blocking JNK, ERK, and NF-κB Signaling Pathways in LPS-Stimulated RAW 264.7 Cells
por: Wei, Juan, et al.
Publicado: (2015)

The Anti-neuroinflammatory Activity of Tectorigenin Pretreatment via Downregulated NF-κB and ERK/JNK Pathways in BV-2 Microglial and Microglia Inactivation in Mice With Lipopolysaccharide
por: Lim, Hye-Sun, et al.
Publicado: (2018)

Azilsartan Modulates HMGB1/NF-κB/p38/ERK1/2/JNK and Apoptosis Pathways during Renal Ischemia Reperfusion Injury
por: Alaaeldin, Rania, et al.
Publicado: (2023)

Corrigendum: Bushen huoxue decoction inhibits RANKL-stimulated osteoclastogenesis and glucocorticoid-induced bone loss by modulating the NF-κB, ERK, and JNK signaling pathways
por: Liu, Yamei, et al.
Publicado: (2023)

Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling
por: Meng, Yanxiang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_p621ka1k9vh66gloipkllf6sf3