High anti-tumor activity of a novel alpha-fetoprotein-maytansinoid conjugate targeting alpha-fetoprotein receptors in colorectal cancer xenograft model

The alpha-fetoprotein receptor (AFPR) is a novel target for cancer therapeutics. It is expressed on most cancers and myeloid derived suppressor cells (MDSCs) but generally absent on normal tissues. Studies were performed to investigate the use of recombinant human AFP (ACT-101) conjugated with mayta...

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Detalles Bibliográficos
Autores principales: Griffin, Patricia, Hill, Wendy A., Rossi, Fabio, Boohaker, Rebecca, Stinson, Karr, Sherman, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074858/
https://www.ncbi.nlm.nih.gov/pubmed/37016369
http://dx.doi.org/10.1186/s12935-023-02910-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074858/
https://www.ncbi.nlm.nih.gov/pubmed/37016369
http://dx.doi.org/10.1186/s12935-023-02910-0

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