ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience

The LIM homeodomain transcription factors LMX1A and LMX1B are essential mediators of midbrain dopaminergic neuronal (mDAN) differentiation and survival. Here we show that LMX1A and LMX1B are autophagy transcription factors that provide cellular stress protection. Their suppression dampens the autoph...

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Detalles Bibliográficos
Autores principales: Jiménez-Moreno, Natalia, Kollareddy, Madhu, Stathakos, Petros, Moss, Joanna J., Antón, Zuriñe, Shoemark, Deborah K., Sessions, Richard B., Witzgall, Ralph, Caldwell, Maeve, Lane, Jon D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075225/
https://www.ncbi.nlm.nih.gov/pubmed/37014324
http://dx.doi.org/10.1083/jcb.201910133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075225/
https://www.ncbi.nlm.nih.gov/pubmed/37014324
http://dx.doi.org/10.1083/jcb.201910133

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