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ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience
The LIM homeodomain transcription factors LMX1A and LMX1B are essential mediators of midbrain dopaminergic neuronal (mDAN) differentiation and survival. Here we show that LMX1A and LMX1B are autophagy transcription factors that provide cellular stress protection. Their suppression dampens the autoph...
Autores principales: | Jiménez-Moreno, Natalia, Kollareddy, Madhu, Stathakos, Petros, Moss, Joanna J., Antón, Zuriñe, Shoemark, Deborah K., Sessions, Richard B., Witzgall, Ralph, Caldwell, Maeve, Lane, Jon D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075225/ https://www.ncbi.nlm.nih.gov/pubmed/37014324 http://dx.doi.org/10.1083/jcb.201910133 |
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