Cargando…

A novel integrative multi-omics approach to unravel the genetic determinants of rare diseases with application in sinusoidal obstruction syndrome

BACKGROUND: Genotype-phenotype analyses of rare diseases often suffer from a lack of power, due to small sample size, which makes identifying significant associations difficult. Sinusoidal obstruction syndrome (SOS) of the liver is a rare but life-threatening complication of hematopoietic stem cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Waespe, Nicolas, Mlakar, Simona Jurkovic, Dupanloup, Isabelle, Rezgui, Mohamed Aziz, Bittencourt, Henrique, Krajinovic, Maja, Kuehni, Claudia E., Nava, Tiago, Ansari, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075428/ https://www.ncbi.nlm.nih.gov/pubmed/37018234 http://dx.doi.org/10.1371/journal.pone.0281892

Ejemplares similares

Genetic Predictors for Sinusoidal Obstruction Syndrome—A Systematic Review
por: Waespe, Nicolas, et al.
Publicado: (2021)

Correction to: GSTM1 and GSTT1 double null genotypes determining cell fate and proliferation as potential risk factors of relapse in children with hematological malignancies after hematopoietic stem cell transplantation
por: Jurkovic Mlakar, Simona, et al.
Publicado: (2021)

GSTM1 and GSTT1 double null genotypes determining cell fate and proliferation as potential risk factors of relapse in children with hematological malignancies after hematopoietic stem cell transplantation
por: Jurkovic Mlakar, Simona, et al.
Publicado: (2021)

Association of CTH variant with sinusoidal obstruction syndrome in children receiving intravenous busulfan and cyclophosphamide before hematopoietic stem cell transplantation
por: Huezo-Diaz Curtis, P, et al.
Publicado: (2018)

A potential implication of UDP-glucuronosyltransferase 2B10 in the detoxification of drugs used in pediatric hematopoietic stem cell transplantation setting: an in silico investigation
por: Robin, Shannon, et al.
Publicado: (2022)

Correction to: A potential implication of UDP-glucuronosyltransferase 2B10 in the detoxification of drugs used in pediatric hematopoietic stem cell transplantation setting: an in silico investigation
por: Robin, Shannon, et al.
Publicado: (2022)

The analysis of GSTA1 promoter genetic and functional diversity of human populations
por: Mlakar, Vid, et al.
Publicado: (2021)

The Biological and Clinical Relevance of G Protein-Coupled Receptors to the Outcomes of Hematopoietic Stem Cell Transplantation: A Systematized Review
por: Golay, Hadrien, et al.
Publicado: (2019)

Association study of candidate DNA-repair gene variants and acute graft versus host disease in pediatric patients receiving allogeneic hematopoietic stem-cell transplantation
por: Uppugunduri, C. R. S., et al.
Publicado: (2021)

The Association of Combined GSTM1 and CYP2C9 Genotype Status with the Occurrence of Hemorrhagic Cystitis in Pediatric Patients Receiving Myeloablative Conditioning Regimen Prior to Allogeneic Hematopoietic Stem Cell Transplantation
por: Uppugunduri, Chakradhara Rao S., et al.
Publicado: (2017)

A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma
por: Mlakar, Vid, et al.
Publicado: (2021)

GSTA1 diplotypes affect busulfan clearance and toxicity in children undergoing allogeneic hematopoietic stem cell transplantation: a multicenter study
por: Ansari, Marc, et al.
Publicado: (2017)

Predictors for participation in DNA self-sampling of childhood cancer survivors in Switzerland
por: Waespe, Nicolas, et al.
Publicado: (2021)

11q deletion in neuroblastoma: a review of biological and clinical implications
por: Mlakar, Vid, et al.
Publicado: (2017)

Influence of glutathione S-transferase gene polymorphisms on busulfan pharmacokinetics and outcome of hematopoietic stem-cell transplantation in thalassemia pediatric patients
por: Ansari, M, et al.
Publicado: (2016)

Pharmacogenomics in Pediatric Oncology: Review of Gene—Drug Associations for Clinical Use †
por: Mlakar, Vid, et al.
Publicado: (2016)

Cemiplimab-Associated Sinusoidal Obstruction Syndrome
por: Sarsour, Nadeen Y., et al.
Publicado: (2023)

PRIMA-1(MET)-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level
por: Mlakar, Vid, et al.
Publicado: (2019)

Pharmacokinetics-adapted Busulfan-based myeloablative conditioning before unrelated umbilical cord blood transplantation for myeloid malignancies in children
por: Benadiba, Joy, et al.
Publicado: (2018)

ADRA2A is involved in neuro-endocrine regulation of bone resorption
por: Mlakar, Vid, et al.
Publicado: (2015)

Unraveling the role of liver sinusoidal endothelial cells in COVID-19 liver injury
por: Saviano, Antonio, et al.
Publicado: (2021)

Cohort-based association study of germline genetic variants with acute and chronic health complications of childhood cancer and its treatment: Genetic Risks for Childhood Cancer Complications Switzerland (GECCOS) study protocol
por: Waespe, Nicolas, et al.
Publicado: (2022)

Opposite Effects of GSTM1 – and GSTT1 – Gene Deletion Variants on Bone Mineral Density
por: Mlakar, Simona Jurkovic, et al.
Publicado: (2011)

The Antioxidant Enzyme GPX1 Gene Polymorphisms Are Associated with Low BMD and Increased Bone Turnover Markers
por: Mlakar, Simona Jurkovic, et al.
Publicado: (2010)

Precision dosing of intravenous busulfan in pediatric hematopoietic stem cell transplantation: Results from a multicenter population pharmacokinetic study
por: Ben Hassine, Khalil, et al.
Publicado: (2021)

Sinusoidal obstruction syndrome after oxaliplatin-based chemotherapy
por: Seo, An Na, et al.
Publicado: (2014)

Diagnosis of sinusoidal obstruction syndrome: can biopsy be the key?
por: Kriege, Oliver, et al.
Publicado: (2023)

Treprostinil reduces endothelial damage in murine sinusoidal obstruction syndrome
por: Themanns, Madeleine, et al.
Publicado: (2018)

Sinusoidal Obstruction Syndrome (SOS) in Multiple Myeloma with Renal Failure
por: Shah, Urvi A., et al.
Publicado: (2018)

Busulfan: Sinusoidal obstruction syndrome with thrombotic microangiopathy: case report
Publicado: (2021)

Molecular Advances in Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease
por: Mavrikou, Ioulia, et al.
Publicado: (2023)

Independent Component Analysis for Unraveling the Complexity of Cancer Omics Datasets
por: Sompairac, Nicolas, et al.
Publicado: (2019)

integrOmics: an R package to unravel relationships between two omics datasets
por: Lê Cao, Kim-Anh, et al.
Publicado: (2009)

Diagnosing Preclinical Cardiac Dysfunction in Swiss Childhood Cancer Survivors: Protocol for a Single-Center Cohort Study
por: Schindera, Christina, et al.
Publicado: (2020)

An integrative omics approach to unravel toxicity mechanisms of environmental chemicals: effects of a formulated herbicide
por: Simões, Tiago, et al.
Publicado: (2018)

Biomarkers for hepatic sinusoidal obstruction syndrome after hematopoietic cell transplantation
por: Lee, Je-Hwan
Publicado: (2015)

Peripheral hepatic sinusoidal obstruction syndrome due to oxaliplatin‐based chemotherapy
por: Kobayashi, Shinichiro, et al.
Publicado: (2019)

Noninvasive imaging diagnosis of sinusoidal obstruction syndrome: a pictorial review
por: Zhang, Yun, et al.
Publicado: (2019)

Hepatomegaly Associated with Non-Obstructive Sinusoidal Dilation in Experimental Visceral Leishmaniasis
por: Maeda, Kota, et al.
Publicado: (2021)

Usefulness of ultrasonography and elastography in diagnosing oxaliplatin-induced sinusoidal obstruction syndrome
por: Saito, Rika, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_goq792mj8vcqtid7jpm25puoi2