Design, synthesis and biological evaluation of novel histone deacetylase (HDAC) inhibitors derived from β-elemene scaffold

β-Elemene is the major active ingredient of TCM anticancer drug elemene extracts. To further improve its antitumor activity and poor solubility, a polar HDACi pharmacophore was incorporated its scaffold. Systematic SAR studies led to the discovery of compounds 27f and 39f, which exhibited potent inh...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Yuan, Duan, Jilong, Dang, Xiawen, Yuan, Yinghui, Wang, Yu, He, Xingrui, Bai, Renren, Ye, Xiang-Yang, Xie, Tian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075517/
https://www.ncbi.nlm.nih.gov/pubmed/37013860
http://dx.doi.org/10.1080/14756366.2023.2195991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075517/
https://www.ncbi.nlm.nih.gov/pubmed/37013860
http://dx.doi.org/10.1080/14756366.2023.2195991

Ejemplares similares