Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression

Abnormal subchondral bone remodeling featured by overactivated osteoclastogenesis leads to articular cartilage degeneration and osteoarthritis (OA) progression, but the mechanism is unclear. We used lymphocyte cytosolic protein 1 (Lcp1) knockout mice to suppress subchondral osteoclasts in a mice OA...

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Detalles Bibliográficos
Autores principales: Zhang, Hao, Wang, Lipeng, Cui, Jin, Wang, Sicheng, Han, Yafei, Shao, Hongda, Wang, Cheng, Hu, Yan, Li, Xiaoqun, Zhou, Qirong, Guo, Jiawei, Zhuang, Xinchen, Sheng, Shihao, Zhang, Tao, Zhou, Dongyang, Chen, Jiao, Wang, Fuxiao, Gao, Qianmin, Jing, Yingying, Chen, Xiao, Su, Jiacan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075992/
https://www.ncbi.nlm.nih.gov/pubmed/37018403
http://dx.doi.org/10.1126/sciadv.abo7868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075992/
https://www.ncbi.nlm.nih.gov/pubmed/37018403
http://dx.doi.org/10.1126/sciadv.abo7868

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