Cargando…

Preparation and characterization of nanobodies targeting SARS-CoV-2 papain-like protease

Coronavirus Papain-like protease (PLpro) mediates the cleavage of viral polyproteins and assists the virus escaping from innate immune response. Thus, PLpro is an attractive target for the development of broad-spectrum drugs as it has a conserved structure across different coronaviruses. In this stu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qiao, Huarui, Li, Lingyun, Wang, Lu, Yu, Haijun, Hu, Fangzheng, Zhou, Xin, Yang, Hongzhao, Xu, Jianfeng, Meng, Xiangjing, Geng, Yong, Dai, Yuanyuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076250/ https://www.ncbi.nlm.nih.gov/pubmed/37030644 http://dx.doi.org/10.1016/j.pep.2023.106267

Ejemplares similares

Deubiquitinating Activity of the SARS-CoV Papain-Like Protease
por: Barretto, Naina, et al.
Publicado: (2006)

Structural basis of nanobodies neutralizing SARS-CoV-2 variants
por: Shi, Zhenzhong, et al.
Publicado: (2022)

Crystal structure of SARS-CoV-2 papain-like protease
por: Gao, Xiaopan, et al.
Publicado: (2021)

Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
por: Klemm, Theresa, et al.
Publicado: (2020)

In silico Exploration of Inhibitors for SARS-CoV-2's Papain-Like Protease
por: Huynh, Tien, et al.
Publicado: (2021)

Validation and Invalidation of SARS-CoV-2 Papain-like Protease Inhibitors
por: Ma, Chunlong, et al.
Publicado: (2022)

Targeting SARS-CoV-2 papain-like protease in the postvaccine era
por: Ton, Anh-Tien, et al.
Publicado: (2022)

SARS‐CoV‐2 Papain‐Like Protease: Structure, Function and Inhibition
por: Ullrich, Sven, et al.
Publicado: (2022)

Inhibitor induced conformational changes in SARS-COV-2 papain-like protease
por: Ferreira, Glaucio Monteiro, et al.
Publicado: (2022)

Parthenolide reveals an allosteric mode to inhibit the deISGylation activity of SARS-CoV‑2 papain-like protease: Parthenolide covalently inhibits papain-like protease
por: Zou, Zhihui, et al.
Publicado: (2022)

Natural biflavones are potent inhibitors against SARS-CoV-2 papain-like protease
por: Li, Lingyu, et al.
Publicado: (2022)

Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2
por: Shan, Hengyue, et al.
Publicado: (2021)

Can Papain-like Protease Inhibitors Halt SARS-CoV-2 Replication?
por: Maiti, Biplab K
Publicado: (2020)

Molecular docking of potential SARS-CoV-2 papain-like protease inhibitors
por: Li, Daoqun, et al.
Publicado: (2021)

In silico analysis of SARS-CoV-2 papain-like protease potential inhibitors
por: Elseginy, Samia A., et al.
Publicado: (2021)

An extended conformation of SARS-CoV-2 main protease reveals allosteric targets
por: Sun, Zengchao, et al.
Publicado: (2022)

Structural and biochemical characterization of SADS‐CoV papain‐like protease 2
por: Wang, Lu, et al.
Publicado: (2020)

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity
por: Shin, Donghyuk, et al.
Publicado: (2020)

SARS-CoV-2 Papain-Like Protease Potential Inhibitors—In Silico Quantitative Assessment
por: Stasiulewicz, Adam, et al.
Publicado: (2021)

Potent and Selective Covalent Inhibition of the Papain-like Protease from SARS-CoV-2
por: Sanders, Brian, et al.
Publicado: (2022)

Atomistic-Level Description of the Covalent Inhibition of SARS-CoV-2 Papain-like Protease
por: Hognon, Cécilia, et al.
Publicado: (2022)

Genetically Encoded Fluorescent Sensors for SARS-CoV-2 Papain-like Protease PLpro
por: Sokolinskaya, Elena L., et al.
Publicado: (2022)

Potent and Selective Covalent Inhibition of the Papain-like Protease from SARS-CoV-2
por: Sanders, Brian, et al.
Publicado: (2022)

In-silico docking studies of selected phytochemicals against papain like protease of SARS-Cov-2
por: Saranya, Palanisamy, et al.
Publicado: (2022)

Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2
por: Sanders, Brian C., et al.
Publicado: (2023)

High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors
por: Zang, Yi, et al.
Publicado: (2022)

Role of Papain-Like Cysteine Proteases in Plant Development
por: Liu, Huijuan, et al.
Publicado: (2018)

Insights Into Dynamics of Inhibitor and Ubiquitin-Like Protein Binding in SARS-CoV-2 Papain-Like Protease
por: Bosken, Yuliana K., et al.
Publicado: (2020)

MERS-CoV papain-like protease has deISGylating and deubiquitinating activities
por: Mielech, Anna M., et al.
Publicado: (2014)

Identification of the antithrombotic protein S as a potential target of the SARS-CoV-2 papain-like protease
por: Ruzicka, Jan A.
Publicado: (2020)

Supporting SARS-CoV-2 Papain-Like Protease Drug Discovery: In silico Methods and Benchmarking
por: Ibrahim, Tamer M., et al.
Publicado: (2020)

Supercomputing, Docking and Quantum Mechanics in Quest for Inhibitors of Papain-like Protease of SARS-CoV-2
por: Sulimov, A. V., et al.
Publicado: (2021)

Hydrazones and Thiosemicarbazones Targeting Protein-Protein-Interactions of SARS-CoV-2 Papain-like Protease
por: Ewert, Wiebke, et al.
Publicado: (2022)

A Review of In Silico Research, SARS-CoV-2, and Neurodegeneration: Focus on Papain-Like Protease
por: Rieder, Alessandra S., et al.
Publicado: (2022)

Discovery of the Cryptic Sites of SARS-CoV-2 Papain-like Protease and Analysis of Its Druggability
por: Qiu, Yue, et al.
Publicado: (2022)

An electrochemical biosensor for SARS-CoV-2 detection via its papain-like cysteine protease and the protease inhibitor screening
por: Liang, Qizhi, et al.
Publicado: (2023)

Pharmacoinformatic study of inhibitory potentials of selected flavonoids against papain-like protease and 3-chymotrypsin-like protease of SARS-CoV-2
por: Tijjani, Habibu, et al.
Publicado: (2022)

Inhibitor Recognition Specificity of MERS-CoV Papain-like Protease May Differ from That of SARS-CoV
por: Lee, Hyun, et al.
Publicado: (2015)

Selectivity in ISG15 and ubiquitin recognition by the SARS coronavirus papain-like protease
por: Lindner, Holger A., et al.
Publicado: (2007)

Structural and functional characterization of MERS coronavirus papain-like protease
por: Lin, Min-Han, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_v0d0bjd4arcblvtl95oeeicvdc