Let-7b-5p inhibits breast cancer cell growth and metastasis via repression of hexokinase 2-mediated aerobic glycolysis

Hexokinase 2 (HK2), a critical rate-limiting enzyme in the glycolytic pathway catalyzing hexose phosphorylation, is overexpressed in multiple human cancers and associated with poor clinicopathological features. Drugs targeting aerobic glycolysis regulators, including HK2, are in development. However...

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Detalles Bibliográficos
Autores principales: Li, Ling, Zhang, Xiujuan, Lin, Yanni, Ren, Xinxin, Xie, Tian, Lin, Jing, Wu, Shumeng, Ye, Qinong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076263/
https://www.ncbi.nlm.nih.gov/pubmed/37019900
http://dx.doi.org/10.1038/s41420-023-01412-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076263/
https://www.ncbi.nlm.nih.gov/pubmed/37019900
http://dx.doi.org/10.1038/s41420-023-01412-2

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